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KMID : 0895820150250010017
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Journal of Oriental Rehabilitation Medicine
2015 Volume.25 No. 1 p.17 ~ p.26
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Experimental Study of Lonicerae Caulis and Bee-venom Acupuncture on the Rheumatic Pathologic Model Induced by Adjuvant in Rats
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Bae Myung-Hyun
Yeom Seung-Ryong
Kim Jin-hee
Kwon Young-Dal
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Abstract
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Objectives : This study was carried out to investigate the experimental effects of Lonicerae Caulis and Bee-venom Acupuncture in Yanglingquan (陽陵泉, GB34) that have clinical efficacy in the Rheumatoid Arthritis.
Methods : Materials of present study are Lonicerae Caulis Extracts (LCE), Bee-Venom Acupuncture (BVP), Sprague-dawley rats (250 g or so, ♂), and various kinds of needing experimental studies. We measured several experimental items of the rats with the arthritis induced by Freund``s complete adjuvant (0.2 ml/kg), such as body weight, rate of paw edema, analgesic effect by hot plate method, WBC, TNF-α cytokine and IL-10 cytokine. Rats were divided into four groups; Normal group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to normal rats, Control group that was treated with normal saline 1.0 ml (o.p) and 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, Experimental group A that was treated with LCE 1.0 ml (o.p) and normal saline 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg and Experimental group B that was treated with LCE 1.0 ml (o.p) and BVP 15 μl/kg (GB34) to pathologic model rats induced by Freund``s complete adjuvant 0.2 ml/kg, and the experiment took over after 28 days. The results were analysed using SPSS for windows 12.0.
Results : Experimental group A showed the increase in body weight, paw licking times and IL-10 cytokine compared to Control group. Also it was decreased in rate of paw edema, WBC, and TNF-α cytokine compared with Control group. Experimental group B showed the increase in body weight, paw licking times, and IL-10 cytokine compared to Control group, and showed the decrease in rate of paw edema, WBC and TNF-α cytokine compared to Control group. Especially TNF-α cytokine and rate of paw edema were accepted statistical significance compared with Control group.
Conclusions : It is suggested that Lonicerae Caulis (o.p) and Bee-venom Acupuncture (GB34) can be used in the treatment of rheumatoid arthritis.
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KEYWORD
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Lonicerae Caulis, Bee-venom Acupuncture, Yanglingquan, GB34, Rheumatoid Arthritis, Freund`s complete adjuvant
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